Citation: | Shiyu Li, Yuanshun Tan, Xiaodan Sun, Yu Mu. AN EPIDEMIC MODEL COUPLED WITH ENVIRONMENTAL LEVEL: EXPLORE THE IMPACT OF DISEASE AWARENESS ON DIRECT AND INDIRECT TRANSMISSION[J]. Journal of Applied Analysis & Computation, 2025, 15(3): 1374-1397. doi: 10.11948/20240230 |
To study the impact of disease awareness on infectious diseases with direct and indirect transmission, we develop a mathematical model by coupling the transmission dynamics at the population level and the environmental level. The basic reproduction number $R_0$ of the coupled model is calculated, and the existence and stability of the disease-free and endemic equilibrium are analyzed in detail. By using center manifold theory, it is verified that the model undergoes backward bifurcation under certain conditions. Numerical simulations verify our theoretical results and indicate that enhancing disease awareness can help reduce both the risk of direct and indirect disease transmission. Interestingly, increasing disease awareness decreases the backward regime of the bifurcation curve, thereby the $R_0$ interval in which the endemic equilibrium and the disease-free equilibrium showed bistability becomes smaller, and the $R_0$ interval in which the disease-free equilibrium showed global stability becomes greater. If the disease cannot be eliminated, the number of infected persons at the steady state decreases with the increase in disease awareness. The findings have certain reference values for the development of effective non-pharmaceutical intervention policies.
[1] | G. O. Agaba, Y. N. Kyrychko and K. B. Blyuss, Mathematical model for the impact of awareness on the dynamics of infectious diseases, Mathematical Biosciences, 2017, 286, 22–30. doi: 10.1016/j.mbs.2017.01.009 |
[2] | A. Aili, Z. D. Teng and L. Zhang, Dynamics in a disease transmission model coupled virus infection in host with incubation delay and environmental effects, Journal of Applied Mathematics and Computing, 2022, 68(6), 4331–4359. doi: 10.1007/s12190-022-01709-y |
[3] | D. Aldila, Optimal control for dengue eradication program under the media awareness effect, International Journal of Nonlinear Sciences and Numerical Simulation, 2023, 24(1), 95–122. doi: 10.1515/ijnsns-2020-0142 |
[4] | A. A. Anteneh, Y. M. Bazezew, S. Palanisamy, et al., Mathematical model and analysis on the impact of awareness campaign and asymptomatic human immigrants in the transmission of COVID-19, BioMed Research International, 2022, 2022(1), 6260262. doi: 10.1155/2022/6260262 |
[5] | F. A. Basir, A. Banerjee and S. Ray, Exploring the effects of awareness and time delay in controlling malaria disease propagation, Optimal Control Applications and Methods, 2021, 22(6), 665–683. |
[6] | Y. C. Bo, C. Song, J. F. Wang, et al., Using an autologistic regression model to identify spatial risk factors and spatial risk patterns of hand, foot and mouth disease (HFMD) in Mainland China, BMC Public Health, 2014, 14, 1–13. doi: 10.1186/1471-2458-14-1 |
[7] | D. Chac, C. N. Dunmire, J. Singh, et al., Update on environmental and host factors impacting the risk of Vibrio cholerae infection, ACS Infectious Diseases, 2021, 7(5), 1010–1019. doi: 10.1021/acsinfecdis.0c00914 |
[8] | C. Castillo-Chavez and B. J. Song, Dynamical models of tuberculosis and their applications, Mathematical Biosciences and Engineering, 2004, 1(2), 361–404. doi: 10.3934/mbe.2004.1.361 |
[9] | F. Colavita, D. Lapa, F. Carletti, et al., SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection, Annals of Internal Medicine, 2020, 173(3), 242–243. doi: 10.7326/M20-1176 |
[10] | D. K. Das, S. Khajanchi and T. K. Kar, The impact of the media awareness and optimal strategy on the prevalence of tuberculosis, Applied Mathematics and Computation, 2020, 366, 124732. doi: 10.1016/j.amc.2019.124732 |
[11] | O. Diekmann and J. A. P. Heesterbeek, Mathematical Epidemiology of Infectious Diseases: Model Building, Analysis and Interpretation, John Wiley & Sons, Netherlands, 2000. |
[12] | N. V. Doremalen, T. Bushmaker, D. H. Morris, et al., Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1, The New England Journal of Medicine, 2020, 382(16), 1564–1567. doi: 10.1056/NEJMc2004973 |
[13] | P. van den Driessche and J. Watmough, Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission, Mathematical Biosciences, 2002, 180(1), 29–48. |
[14] | Z. L. Feng, J. Velasco-Hernandez and B. Tapia-Santos, A mathematical model for coupling within-host and between-host dynamics in an environmentally-driven infectious disease, Mathematical Biosciences, 2013, 241(1), 49–55. doi: 10.1016/j.mbs.2012.09.004 |
[15] | S. Funk, E. Gilad, C. Watkins, et al., The spread of awareness and its impact on epidemic outbreaks, Proceedings of the National Academy of Sciences, 2009, 106(16), 6872–6877. doi: 10.1073/pnas.0810762106 |
[16] | S. R. Gani and S. V. Halawar, Optimal control for the spread of infectious disease: The role of awareness programs by media and antiviral treatment, Optimal Control Applications and Methods, 2018, 39(4), 1407–1430. doi: 10.1002/oca.2418 |
[17] | D. H. He, X. Y. Wang, D. Z. Gao, et al., Modeling the 2016–2017 Yemen Cholera outbreak with the impact of limited medical resources, Journal of Theoretical Biology, 2018, 451, 80–85. doi: 10.1016/j.jtbi.2018.04.041 |
[18] | T. K. Kar, S. K. Nandi, S. Jana, et al., Stability and bifurcation analysis of an epidemic model with the effect of media, Chaos, Solitons & Fractalss, 2019, 120, 188–199. |
[19] |
J. P. Lasalle, The stability of dynamical systems, Regional Conference Series in Applied Mathematics, SIAM, Philadelphia, 1976. DOI: |
[20] | N. H. L. Leung, Transmissibility and transmission of respiratory viruses, Nature Reviews Microbiology, 2021, 19(8), 528–545. doi: 10.1038/s41579-021-00535-6 |
[21] | S. M. Levine and D. D. Marciniuk, Global impact of respiratory disease: What can we do, together, to make a difference, Chest, 2022, 161(5), 1153–1154. doi: 10.1016/j.chest.2022.01.014 |
[22] | X. W. Li, X. Ni, S. Y. Qian, et al., Chinese guidelines for the diagnosis and treatment of hand, foot and mouth disease (2018 edition), World Journal of Pediatrics, 2018, 14(5), 437–447. doi: 10.1007/s12519-018-0189-8 |
[23] | B. Musundi, J. Müller and Z. L. Feng, A multi-scale model for Cholera outbreaks, Mathematics, 2022, 10(17), 3114. doi: 10.3390/math10173114 |
[24] | E. J. Nelson, J. B. Harris, J. Glenn Morris Jr, et al., Cholera transmission: The host, pathogen and bacteriophage dynamic, Nature Reviews Microbiology, 2009, 7(10), 693–702. doi: 10.1038/nrmicro2204 |
[25] | A. Rzeżutka and N. Cook, Survival of human enteric viruses in the environment and food, FEMS Microbiology Reviews, 2004, 28(4), 441–453. doi: 10.1016/j.femsre.2004.02.001 |
[26] | S. S. Shanta and M. H. A. Biswas, The impact of media awareness in controlling the spread of infectious diseases in terms of SIR model, Mathematical Modelling of Engineering Problems, 2020, 7(3), 368–376. DOI: 10.18280/mmep.070306. |
[27] | X. D. Sun and Y. N. Xiao, Multiscale system for environmentally-driven infectious disease with threshold control strategy, International Journal of Bifurcation and Chaos, 2018, 28(05), 1850064. doi: 10.1142/S0218127418500645 |
[28] | J. D. Tamerius, J. Shaman, W. J. Alonso, et al., Environmental predictors of seasonal influenza epidemics across temperate and tropical climates, PLoS pathogens, 2013, 9(3), e1003194. doi: 10.1371/journal.ppat.1003194 |
[29] | G. N. Sze-To, Y. Yang, J. K. C. Kwan, et al., Effects of surface material, ventilation, and human behavior on indirect contact transmission risk of respiratory infection, Risk Analysis, 2014, 34(5), 818–830. doi: 10.1111/risa.12144 |
[30] | X. Y. Wang, S. P. Wang, J. Wang, et al., A multiscale model of COVID-19 dynamics, Bulletin of Mathematical Biology, 2022, 84(9), 99. doi: 10.1007/s11538-022-01058-8 |
[31] | S. Weston and M. B. Frieman, Respiratory viruses, Encyclopedia of Microbiology, 2019, 85–101. DOI: 10.1016/B978-0-12-801238-3.66161-5. |
[32] | F. Xiao, M. W. Tang, X. B. Zheng, et al., Evidence for gastrointestinal infection of SARS-CoV-2, Gastroenterology, 2020, 158(6), 1831–1833. doi: 10.1053/j.gastro.2020.02.055 |
[33] | Y. N. Xiao, C. C. Xiang, R. A. Cheke, et al., Coupling the macroscale to the microscale in a spatiotemporal context to examine effects of spatial diffusion on disease transmission, Bulletin of Mathematical Biology, 2020, 82(5), 58. doi: 10.1007/s11538-020-00736-9 |
[34] | Y. F. Xing, L. Zhang and X. H. Wang, Modelling and stability of epidemic model with free-living pathogens growing in the environment, Journal of Applied Analysis and Computation, 2020, 10(1), 55–70. doi: 10.11948/20180269 |
[35] | J. C. Zhang, S. B. Wang and Y. D. Xue, Fecal specimen diagnosis 2019 novel coronavirus–infected pneumonia, Journal of Medical Virology, 2020, 92(6), 680–682. doi: 10.1002/jmv.25742 |
Variation in the number of exposed and infected people and virus concentration in the environment under different values of
The impact of
(a) shows that
Taking different initial values,
Bifurcation diagram for different awareness impact factors. (a) shows the backward bifurcation diagram of system (2.1), where the dash curve represents unstable equilibrium while the solid curve represents stable equilibrium. (b) shows the influence of the value of different awareness impact factor